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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8822dbaf5e59ca7242fd13dd1a3eda2979eb40f6bf6f2917a2036aaa73272265' 
  AND token = 'TtOj2KDsgP//4AFuyVV9pT3cQ1YfGrxAET6gmrjnqks=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}