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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af852ed435c63d5044c79ef3ad406903c5b9b05312042928d0303f331b17e0ba' 
  AND token = 'ymhmA7XyIZyPKW+YXNiD28nT0EIC9QFolY+VzfeUbMg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}