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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c4e93fdf1260c7fe5cfd5458cf564c082f7b94bced9dcbd61fd970deed6c280' 
  AND token = 'rN1/PA6grP7NXW43JSCoTvW3zJq3XB/gQJxkZWTC5Is=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}