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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4a91bf1af17d7e43735debe64ec6d4d00ebf46bfc1528720ff728af72a1ca81' 
  AND token = 'cYS59PhPWx/5+Hlb2iXAzpx+Qe08GiGVOz8Dvk3DcXA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}