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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '457242619fc27c98857eda3f518f9aaa33a14b22fa503f93244d715c17c0c5e5' 
  AND token = 'ngFAUH9t5xIHhmrRv7RhiK67kKj2vamT5tb2qkmd0TQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}