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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4949e126627acafdeb1df1ccd9bfff04deb6ee0ef314fe40fa06647090199982' 
  AND token = '74AcwFb2zMQ4fKbkkf5+UBeNcK2soB1L+tTbwlf89po=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}