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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5750aa360fbc5b7adfaa594ebd74e3d8da66d62f5d0fa90b969f18ad83120a8' 
  AND token = 'LwOzVTAfhHv/WFWLnwQjfJcQzIkMKjKMn4HhHk5NKVA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}