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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f56d1d270a352b793bfef9195379842a4a88c20ac36f253024c18632f4d02c' 
  AND token = 'RXJRHIHxtymVtpayh3y8rkdwOVBy49RWR2I/e62fHfI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}