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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d454adbe9b07f48e33cafcfa212c50f1b60c68364ab1bf331ddd9eed1da4adc' 
  AND token = 'iGY4wEQHZh8z4SF9l86aPI6ItxZ62zYtmw/K4a+b2NE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}