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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dfbfed4460c00741bc442589a08383ea0fd6ad7b043aec54722424741e0b900b' 
  AND token = 'JmkS6WlmtRPhhlCMhxI9+Mq/vv+mVviPEK2Ft4WmkuU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}