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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81f672544e2c72b46e7cd36571b0093f977b708be7f5bbded354f6a2e2579aea' 
  AND token = 'EeSoS5pukoV2jKbfM/k28LWx0IPArMc/ctW2ygHv2Pg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}