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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4eb7ca89b5a69f44b2fcf5bb8c826521a605df07d8b81e4c05c4efbf02881da1' 
  AND token = '8+LbDGopZdCBI8hs4HXFhVPeE1Fj3bGIGiIStLiNsB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}