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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '777f81335d202bd2ee27c5a10d24aa5f295f69450ee45bfd5023b34d8e91999a' 
  AND token = 'BW3uqMnB0KWQKEbH45PEApQwReroo5iwFwQa0HPphMA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}