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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42e22ed47f667ef1bb2ae02d80c742793999a7deef364db777c9b0e0e51af6b2' 
  AND token = 'wxIiO29/OCE0D/KLtyORgq56U4uWLoCkcGgSc4X2M34=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}