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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222aaa4d40d4ff3bd6d5b6a0a9de48781c06f53c32a38a3a536e355538ed3b6c' 
  AND token = '/U53Q9FdyPxbOAC7yVU0KQRX66FmqmoC5zLf2nvg/0g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}