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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c4af648d985c2e6a76df9ec30b36a245e79e68e644eb73c3ed75446401755ac' 
  AND token = 'DkTucWPBsXRxLv+oSHsZfhAOOG6hWyiRh08T2fV4bzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}