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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b7d8c7b56e8d885298ca05b15c2f68cdc4b5b54e5e956265ac33fbbcb5bb4166' 
  AND token = 'dPiOg5zIW+QoIheMNDC+8OYWIN7gDfdY05qcDgZP9tQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}