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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ab70b40a980b57bb8e4d368f280bf9565ca7f7cfafc8b573b2186a23274e0b5' 
  AND token = 'bhj+My42/V2syifJOa9vDeZISAX0nEPmThK679Af8so=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}