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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '223b7de1dd61dcc0042cb0e2181da5a33e89e0fc1e45ee8930ff27e9ec8d940e' 
  AND token = 'AMrC/q58RZx3cEhaHQiHlV2NCU6p42qKfxMjB1S3QW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}