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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781cb07272f222f286554d1e87dac4594beeeeb6eaa395845e33f4d5576c07fb' 
  AND token = 'B1fkWT0WlhzMeTmOvvkR3GMM/tH02Xf3Pu3bkxRxZ7M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}