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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a7a2f0fae05f62afe6b7f9b212ff3af9774d155d2f956f7525bea51ebf04d253' 
  AND token = 'JZRIPmEYLTPvAKxomeOWFN/a/ST9UzAQoY22wgAOvWY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}