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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8278566a6a47f2a3ed4a3884ee12c2d742b5561a3cb8bbcb212d4cbc3080ed22' 
  AND token = 'RPt2fv+Iwy+3k53JU96TbPNPJGDnrTDjglqq2Lo6GPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}