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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c7a8011fa0e54168afefdc78c561116b4f30813d4edaf1b68552c6ee6fe7596' 
  AND token = '2JNP5DXtFOaC2qDPQ4zrLL6FXfY/HkpHf0qcHjtUzT8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}