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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729caafef9d505b4509ac8998ec82687d8c8c6f55680732302093476178756dd' 
  AND token = 'UYuWEIMGam7Fj1gfR6Tp27DYdeAWssAboP5X4csnOIU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}