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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1158f4dcda2f11ba01cfd14b22752123deb89fc7991acadb44f1614a9de1363a' 
  AND token = 'ddjRzjhAai0S0UPDOPmNvUzA1LjnwWYibIWFusNldNY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}