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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ac4c9d9d80450bf564c09d33e1111653070e154374d309d9a5e54004e4cea217' 
  AND token = 'kZhRBaeTrwpMclvCbrZA3YqyTDVuPOXO0bItAjXW7m4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}