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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28f6c05a30463d703736a66a15a93a07f1aa47b9785c1a81d37803c2214e79bc' 
  AND token = '8mcF7N88njTCDI5d191P2y8kA6M328ekZDVMOtJortE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}