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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64c4b202c8a92f0120655ab2ec69aff7b62bf9bcd4c860f7b023f16b31961e56' 
  AND token = 'o1k2G5SJGE/0voDYP9av6Pk4cyaxAvmHVSDYfuy1FkE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}