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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7622568ac596bb86dcb1139030f314fe2ceae06e2f19628e7b110c05d5c7e8f4' 
  AND token = 'HXdW0c7PErDy4yvo3pg27SFZEvJKsvJcrbXyRL3+i3Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}