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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af53a0e55d7f2de5de6b4580f8523130f1de2cd7272e940f1fa3907bb6ef3e02' 
  AND token = 'H2AsGq9d6XJfLiSRrEkRk9HDJ+8sL1XMvHcaAvAzXJA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}