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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf395dabbec924c7a644adbc51d19bed462e3c622a5ea49574ee81d356b4b50f' 
  AND token = 'IhTM3HQt3fLUfPSgpx5TtfoqgWqUDT2XMqwSdgpyxcI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}