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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1063dbd45cdc375bc7326ae97f62978a646bdf05305438485a4e5a12f9edd022' 
  AND token = '8iabQC0rDU4MTXCmjKfuwnbkD6M/3WvLqzkYL8iFG/k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}