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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1018ffe44232b21cb6daf2e63a317938ffee89e644e9d4c4e310a23fe155f83f' 
  AND token = 'Eh4b/O4xT0rK/7XJnSrNDEEQYxIVXrgwxLoj0ZpvdrE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}