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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b8c14af3545c7c0709924d2db37e8c9390173f12030040b9d3d0e2d0b14386' 
  AND token = 'n+G2Gg9/PxTdLVb3WAQCuSdvNhdUw56xvp42hNAnkYU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}