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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '563ead6741deb8e77bf2770e1c5db506117de9e9c2dc32399b04d8d1ac8d28dd' 
  AND token = 'aUUaMj6I3sMl5x7SgYOdoVfEZ+KM4mccOiFxbRHiSxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}