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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '443a4214b85c2297558a8422cf7a92d91dc5f6b8a2d5a153799a545e29bed725' 
  AND token = 'pV9vxzshSQ2DlTKl2+PyPrhvOm4sMcdFkv+IDR4/eXs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}