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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed7ba65a4f55439fb83f722ea22a316edddaa3e7e378999a1b8a1352a8a7222a' 
  AND token = 'B0zmCDESAOKVDra7V64pJ+8JjDtUtp8V7hPuUE/1IoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}