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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d76755564be4264cf32da57f3d7465bb94a2a2105860d29c7f7a61288959f42' 
  AND token = '9LxvI2nAplfLwyrjnKl7VM52rS9njM+hK9XpNPKiCr4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}