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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd5a0d3bac76a8a32fa91747dc107528705dbba77a53360db532eca3f044a823' 
  AND token = 'A4yNOx9MmPaHt4HMknEH4P+r9p+/TTfvqPtCzIquAjs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}