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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48eeb0722089aa14556bc188896295bc1b1655bd0fb6147f0a6f5f1710495555' 
  AND token = 'vt6OyA7UWxtqv39eT4TPjf0fx9WWayiB29fWafkDFCM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}