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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75989e9b0f28a12b5a6b3c5069feaadab2877d0defa9079f427ddcab84666e58' 
  AND token = 'EtMvCKkzC1n7MuWMSBAblVCitVJBXHu4sX+Wd8UkdPU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}