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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '77d4f935b8e9a0e44e4657473c47d886cdf0498a5c006a0ccb8bf9debe7d7175' 
  AND token = 'zX2jw4uAnyQbyByE8hiqVCeSe1rLvzROX0n0SMJnBl4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}