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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '345002eb069223a827698f11d616c1e66b89e9e8ee3ace2f2c4d3a270fff2a99' 
  AND token = 'dH9V2h3zRK+NQ9UeF9Va5w2NA5vNtrzTUaVRMb7Iuk8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}