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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b1001cc6f2e2f4682b8dc046e3b4808a89e9e3f0b89a2694ca66db328257d83' 
  AND token = 'By+9lJDk1IYcmYs3OoKNUtVvuOpBwfFUwWaFZ/V11i8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}