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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14be1aec2b9fb9ad0477d208c768dcd1727fbeeb9ded05e6cc05afe9a17e4355' 
  AND token = '4Rwduyi5d6y3C1H1ueixmecNvG+oB+3ZAWkGqmO3Zs4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}