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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f83780ec3b777e426fa5b8c8901e1616f46ebe97cdb0c87a972e82bb38c760a' 
  AND token = 'GH6bx7D3fp7LE+9wrgEP/YYSdcT1WTMS+1xqw1UJ5kc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}