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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f6364811ec1b3545c5ae6fb098e52dd50e82004fe47fbace28f4b79e0d7d0100' 
  AND token = '5+LsmO/MTvWfJdQtHPR38zMcXUsb4M5lyJw+WJhBfto=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}