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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '506e2710f2bd5c081cf1ba2ce20f99802f83d648c52a27ba518f07f45d86a500' 
  AND token = 'dKX5EDgxjCn+YWdsBf1yxRnqCzodf5mgu6XAqfPgSy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}