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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8cd658490c6991e23e459d5fa0a9c0f47d3e130deab4b65d69f5fa483a47821' 
  AND token = 'mz47JIF8VrxsxGpcZCVssWeIK5MWz+ZA21cGBCx1TFc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}