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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af050ce8939719a08bbe9117ca1c1109d25fc9660af3316c626fa3dbdc18a5a2' 
  AND token = 'ab8Hk1O3r3ZRE/AOAamJDttOO4g8QHCHBZzaQ3THhY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}